Pilot study of a cell membrane like biomimetic drug-eluting coronary stent / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 599-602, 2007.
Article
Dans Chinois
| WPRIM
| ID: wpr-357643
ABSTRACT
A novel bioinspired phospholipid copolymer has been synthesized by the radical polymerization of poly2-Methacryloyloxyethylphosphorylcholine (MPC), stearyl methacrylate (SMA), hydroxypropyl methacrylate (HPMA) and trimethoxysilylpropyl methacrylate (TSMA). Contact angle results indicated that the coating surface rearranged to get a more hydrophilic surface at the polymer/water interface. The membrane mimic phosphorylcholine coating surface could resist the platelet adhesion and prolong plasma recalcification time significantly. Rapamycin was used as model drugs to prepare drug-eluting coating. The animal experiments showed that this novel drug-eluting stent could effectively prevent the phenomena of restenosis.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Phosphoryl-choline
/
Polymères
/
Conception de prothèse
/
Suidae
/
Porc miniature
/
Test de matériaux
/
Répartition aléatoire
/
Angioplastie coronaire par ballonnet
/
Chimie
/
Projets pilotes
Type d'étude:
Essai clinique contrôlé
Limites du sujet:
Animaux
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Journal of Biomedical Engineering
Année:
2007
Type:
Article
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