BMP-2 gene carried by biodegradable scaffold and fibrinous gel for repairing segmental radial defect in rabbit / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 345-349, 2007.
Article
Dans Chinois
| WPRIM
| ID: wpr-357701
ABSTRACT
Adenovirus carrying BMP-2 gene, after being mixed with fibrinous gel, was siphoned off on biodegradable scaffolds (PLA/PCL). The composite was used to repair 1.5 cm long radius defect in rabbits. Four methods were in use in the experiments Ad-BMP-2 plus fibrinous gel and PLA/PCL (Group A), reconstructed hBMP-2 plus fibrinous gel and PLA/PCL (Group B), Ad-Lacz plus fibrinous gel and PLA/PCL (Group C), and fibrinous gel and PLA/PCL (Group D). Results showed that the defects treated in Group A were repaired with much more new bone regenerated, bridged earlier and stronger than those in Group B 12 weeks after operation. The defects treated in the other two groups could not attain osseous tissue healing. BMP-2 gene carried by biodegradable scaffold and fibrinous gel is easy to conduct and has very strong osteoinduction ability. It is really a good method to repair segmental bone defects.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Polyesters
/
Polymères
/
Fractures du radius
/
Thérapeutique
/
Matériaux biocompatibles
/
Azépan-2-one
/
Thérapie génétique
/
Adenoviridae
/
Chimie
/
Consolidation de fracture
Limites du sujet:
Animaux
/
Humains
langue:
Chinois
Texte intégral:
Journal of Biomedical Engineering
Année:
2007
Type:
Article
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