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Interferon-γ and interleukin-4 detected in serum and saliva from patients with oral lichen planus / 国际口腔科学杂志·英文版
International Journal of Oral Science ; (4): 22-26, 2014.
Article Dans Anglais | WPRIM | ID: wpr-358159
ABSTRACT
Our previous salivary study had demonstrated an apparent T helper 2 (Th2)-predominance in saliva of oral lichen planus (OLP) patients and suggested a potential of salivary interleukin-4 (IL-4) as a biomarker for monitoring disease severity. To further determine the consistency of Th1/Th2 bias of OLP, this study investigated the expression profile of interferon-γ (IFN-γ) and IL-4 in serum and the relationship of the serum levels of these cytokines with their saliva partners. Sixty ethnic Chinese patients with OLP (40 of the erythematous/ulcerative form and 20 of the reticular form) were recruited for this study, with 40 age-sex-matched healthy volunteers as control group. IFN-γ and IL-4 levels in serum and paired saliva samples were screened by enzyme-linked immunosorbent assay. OLP patient showed a low-level IFN-γ but high-level IL-4 expression profile in both serum and saliva, with a lower IFN-γ/IL-4 ratio. Serum IL-4 level in the erythematous/ulcerative group was significantly higher than that in the reticular group. Serum levels of IFN-γ and IL-4 were significantly and positively correlated with their saliva partners. These results provided more evidence for Th2 cytokine-predominant immune imbalance in OLP, as well as the potential of IL-4 as the biomarker for monitoring severity of OLP.
Sujets)
Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Salive / Sang / Marqueurs biologiques / Études cas-témoins / Chimie / Interleukine-4 / Interféron gamma / Classification / Lichen plan buccal / Lymphocytes auxiliaires Th2 Type d'étude: Étude observationnelle Limites du sujet: Adulte / Femelle / Humains / Mâle langue: Anglais Texte intégral: International Journal of Oral Science Année: 2014 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Salive / Sang / Marqueurs biologiques / Études cas-témoins / Chimie / Interleukine-4 / Interféron gamma / Classification / Lichen plan buccal / Lymphocytes auxiliaires Th2 Type d'étude: Étude observationnelle Limites du sujet: Adulte / Femelle / Humains / Mâle langue: Anglais Texte intégral: International Journal of Oral Science Année: 2014 Type: Article