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Primary superficial small cell neuroendocrine carcinoma of esophagus: clinicopathologic and immunohistochemical analysis of 15 cases / 中华病理学杂志
Chinese Journal of Pathology ; (12): 736-740, 2011.
Article Dans Chinois | WPRIM | ID: wpr-358249
ABSTRACT
<p><b>OBJECTIVE</b>To study the clinicopathologic and immunohistochemical features of primary superficial esophageal small cell neuroendocrine carcinoma (ESCNC).</p><p><b>METHODS</b>The clinical, pathologic and immunohistochemical features were retrospectively analyzed in 15 cases of superficial ESCNC. An immunohistochemical study for chromogranin A, neuron-specific enolase, synaptophysin, CD56, TTF-1, 34βE12, AE1/AE3, and CK10/13 was performed.</p><p><b>RESULTS</b>Superficial ESCNC accounted for 4.8%(15/312) of all cases of superficial carcinoma of the esophagus encountered during the same period. The median survival time was 19 months and the mean survival time was 23.7 months after diagnosis. The one, two and five-year survival rates were 10/15, 5/15 and 1/15, respectively. The immunophenotypic profile was as follows neuron-specific enolase (15/15), synaptophysin (15/15), AE1/AE3 (15/15), CD56 (14/15), TTF-1 (9/15), chromogranin A (8/15), 34βE12 (1/15) and CK10/13 (0/15).</p><p><b>CONCLUSIONS</b>Superficial ESCNC is a rare and aggressive malignant tumor with poor prognosis. Surgical resection coupled with post-operative chemoradiotherapy is the mainstay of treatment. The immunohistochemical study is valuable in pathologic diagnosis and differential diagnosis.</p>
Sujets)
Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Anatomopathologie / Enolase / Chirurgie générale / Facteurs de transcription / Tumeurs de l&apos;oesophage / Immunohistochimie / Protéines nucléaires / Taux de survie / Études rétrospectives / Études de suivi Type d'étude: Étude observationnelle / Étude pronostique Limites du sujet: Adulte / Adulte très âgé / Aged80 / Femelle / Humains / Mâle langue: Chinois Texte intégral: Chinese Journal of Pathology Année: 2011 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Anatomopathologie / Enolase / Chirurgie générale / Facteurs de transcription / Tumeurs de l&apos;oesophage / Immunohistochimie / Protéines nucléaires / Taux de survie / Études rétrospectives / Études de suivi Type d'étude: Étude observationnelle / Étude pronostique Limites du sujet: Adulte / Adulte très âgé / Aged80 / Femelle / Humains / Mâle langue: Chinois Texte intégral: Chinese Journal of Pathology Année: 2011 Type: Article