Clinical study of zoledronic acid in the treatment of cancer-induced hypercalcemia / 中华肿瘤杂志
Chinese Journal of Oncology
; (12): 632-634, 2005.
Article
de Zh
| WPRIM
| ID: wpr-358550
Bibliothèque responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect and safety of zoledronic acid (Zoledex) in patients with cancer-induced hypercalcemia.</p><p><b>METHODS</b>Seventeen patients with cancer-induced hypercalcemia (corrected blood calcium > 2.70 mmol/L) were treated intravenously by 4 mg zoledex within 15 minutes on the first day. The corrected blood calcium was observed every 4 days in the following 28 days.</p><p><b>RESULTS</b>The response rate was 94.1% (16/17). The mean corrected blood calcium became normal after the first dose of zoledex (P < 0.01). The lowest value was found on the fourteenth day after treatment. The main side effects consisted of fever (29.4%, 5/17), hypocalcemic tetany (11.8%, 2/17) and arythmia (5.9%, 1/17).</p><p><b>CONCLUSION</b>Zoledex is effective and safe in the treatment of patient with cancer-induced hypercalcemia.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Sécurité
/
Utilisations thérapeutiques
/
Diphosphonates
/
Traitement médicamenteux
/
Agents de maintien de la densité osseuse
/
Hypercalcémie
/
Imidazoles
/
Tumeurs
Limites du sujet:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
langue:
Zh
Texte intégral:
Chinese Journal of Oncology
Année:
2005
Type:
Article