Experience of gemcitabine plus cisplatin chemotherapy in 52 patients with head and neck cancer / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 567-569, 2005.
Article
Dans Chinois
| WPRIM
| ID: wpr-358568
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the efficacy and toxicity of combination chemotherapy using gemcitabine plus cisplatin for recurrent and/or metastastic head and neck cancer patients.</p><p><b>METHODS</b>Fifty-two patients with recurrent or metastatic head and neck cancer were treated by gemcitabine 1000 mg/m(2) on D1, 8 and cisplatin 25 mg/m(2) on D1 approximately 3 every 21 days as one cycle.</p><p><b>RESULTS</b>Of 52 assessable patients, 3 (5.8%) showed complete response and 19 (36.5%) partial response with an overall response rate of 42.3% (22/52). Median time to progression was 5.0 months, and 1-year survival was 43.4% with a median survival time of 9.9 months. Of 32 previously treated patients by cisplatin-containing regimen, 2 patients (6.3%) gave complete response and 11 (34.4%) partial response with an overall response rate of 40.6% (13/32). Median time to progression was 3.4 months, and 1-year survival was 29.2% with a median survival time of 8.3 months. Toxicity mainly included grade 1/2 myleosuppression, rash and nausea/vomiting.</p><p><b>CONCLUSION</b>Gemcitabine plus cisplatin chemotherapy is safe and effective for patients with recurrent and/or metastastic head and neck cancer.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Carcinome épidermoïde
/
Protocoles de polychimiothérapie antinéoplasique
/
Tumeurs du rhinopharynx
/
Cisplatine
/
Utilisations thérapeutiques
/
Désoxycytidine
/
Traitement médicamenteux
/
Tumeurs de la tête et du cou
/
Métastase tumorale
Limites du sujet:
Adolescent
/
Adulte
/
Adulte très âgé
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Chinese Journal of Oncology
Année:
2005
Type:
Article
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