Efficacy of concurrent radio-chemotherapy and chemotherapy alone in the treatment of locally advanced non-small-cell lung cancer / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 502-504, 2005.
Article
Dans Chinois
| WPRIM
| ID: wpr-358589
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the effect and acute toxicity of concurrent radio-chemotherapy, by NVB and DDP, plus concurrent radiotherapy in comparison with chemotherapy alone in the treatment of inoperable locally advanced non-small-cell lung cancer (LANSCLC).</p><p><b>METHODS</b>Sixty-four patients with inoperable LANSCLC were randomly divided by envelope method into two groups concurrent radio-chemotherapy group (n = 33) and conventional chemotherapy group (n = 31). The patients in conventional chemotherapy group were treated by NP regimen (NVB + DDP) NVB 25 mg/m(2), d1, 8 and DDP 25-30 mg/m(2) d1-3. In the radio-chemotherapy group by NP regimen plus conventional radiotherapy by (60)Co 64-68 Gy/2 Gy x 5/w x 6-7w.</p><p><b>RESULTS</b>All patients completed the treatment schedule. The overall response rate (CR + PR) in the radio-chemotherapy group was significantly higher than that in the conventional chemotherapy group 81.8% vs 45.2%, (P < 0.01) with 1- and 2-year survival rates of 69.7% vs 38.7% (P < 0.05) and 39.4% vs 16.1% (P < 0.05). without any significant difference in the acute toxicity between two groups (P > 0.05).</p><p><b>CONCLUSION</b>Compared with conventional chemotherapy (NVP and DDP), concurrent radio-chemotherapy (NVP and DDP plus concurrent radiotherapy) is more effective and tolerable for the inoperable locally advanced non-small-cell lung cancer.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Radiosensibilisants
/
Radiothérapie
/
Vinblastine
/
Protocoles de polychimiothérapie antinéoplasique
/
Cisplatine
/
Association thérapeutique
/
Carcinome pulmonaire non à petites cellules
/
Utilisations thérapeutiques
/
Traitement médicamenteux
/
Tumeurs du poumon
Limites du sujet:
Adulte
/
Adulte très âgé
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Chinese Journal of Oncology
Année:
2005
Type:
Article
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