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Effect of iptkalim on myocardial enzymes and free radicals metabolism with hypoxic pulmonary hypertension / 中国应用生理学杂志
Chinese Journal of Applied Physiology ; (6): 385-388, 2012.
Article Dans Chinois | WPRIM | ID: wpr-358735
ABSTRACT
<p><b>OBJECTIVE</b>To explore the effects of iptkalim on myocardial enzymes and free radicals metabolism with hypoxic pulmonary hypertension (HPH), in order to provide evidence for the mechanism of iptkalim on clinical treat.</p><p><b>METHODS</b>110 young men stayed at high altitude above 5 000 m were divided into iptkalim group (n = 74) and placebo group (n = 36), aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyltransferase (gamma-GT), creatine kinase (CK), lactate dehydrogenase (LDH), superoxide dismutase (SOD), malonaldehyde (MDA), nitric oxide(NO) and nitric oxide synthase(NOS) were detected before and after took medicines for 6 mouths.</p><p><b>RESULTS</b>After took medication for 6 mouths, ALT, AST, gamma-GT, CK and LDH were reduced, SOD, NO, and NOS were increased, MDA were reduced, there were very significant difference (P < 0.05).</p><p><b>CONCLUSION</b>Oxygen free radicals have taken part in the process of HPH, iptkalim have the effect of anti-peroxidation of lipid and protect myocardial cells stress injured by hypoxia which related with mitochondrial membrane and cell membrane's K(ATP) channel activation.</p>
Sujets)
Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Pharmacologie / Propylamines / Sang / Canaux potassiques / Creatine kinase / Altitude / Radicaux libres / Hypertension pulmonaire / L-Lactate dehydrogenase / Hypoxie Type d'étude: Essai clinique contrôlé Limites du sujet: Adolescent / Adulte / Humains / Mâle langue: Chinois Texte intégral: Chinese Journal of Applied Physiology Année: 2012 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Pharmacologie / Propylamines / Sang / Canaux potassiques / Creatine kinase / Altitude / Radicaux libres / Hypertension pulmonaire / L-Lactate dehydrogenase / Hypoxie Type d'étude: Essai clinique contrôlé Limites du sujet: Adolescent / Adulte / Humains / Mâle langue: Chinois Texte intégral: Chinese Journal of Applied Physiology Année: 2012 Type: Article