Negative results ofumu genotoxicity test of fluorotelomer alcohols and perfluorinated alkyl acids
Environmental Health and Preventive Medicine
;
: 217-219, 2007.
Article
Dans Anglais
| WPRIM
| ID: wpr-359839
ABSTRACT
<p><b>OBJECTIVES</b>Recently, perfluorooctanoate (PFOA) has been ubiquitously detected in the environment as well as in human serum. Fluorotelomer alcohols (FTOHs), a precursor of PFOA, undergo biodegradation via several metabolic routes which leads to formation of various biodegradation products. The degradation of FTOHs produces an α,β-unsaturated aldehyde that seems possibly to be electrophilic and may react with cellular macromolecules including DNA.</p><p><b>METHODS</b>We investigated the genotoxicity of three FTOHs (6∶2 FTOH, 8∶2 FTOH and 10∶2 FTOH), PFOA and perfluorooctane sulfonate (PFOS) using theumu test.</p><p><b>RESULTS</b>The FTOHs, PFOA and PFOS showed no significant increases in β-galactosidase activity at 0-1000 μM in the absence of S9 mix. The results were unchanged by the metabolic activation with S9 mix.</p><p><b>CONCLUSION</b>The genotoxicities of FTOHs, PFOA or PFOS are not detectable using the present method, suggesting that they are unlikely mutagens.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Anglais
Texte intégral:
Environmental Health and Preventive Medicine
Année:
2007
Type:
Article
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