Genetic polymorphism of glutathione S-transferase T1 gene and susceptibility to idiopathic azoospermia or oligospermia in northwestern China / 亚洲男科学杂志(英文版)
Asian Journal of Andrology
;
(6): 266-270, 2008.
Article
Dans Anglais
| WPRIM
| ID: wpr-359981
ABSTRACT
<p><b>AIM</b>To investigate the association of glutathione S-transferase T1 (GSTT1) gene polymorphism in patients with idiopathic azoospermia or oligospermia in the northwestern China population.</p><p><b>METHODS</b>In the case-control study, GSTT1 genotypes were identified by multiplex polymerase chain reaction (PCR) with peripheral blood DNA samples from 78 patients with idiopathic azoospermia, 103 patients with idiopathic oligospermia and 156 age-matched controls with normal sperm concentration and motility, according to the criteria adapted from World Health Organization guidelines. All of the patients and controls were from northwestern China.</p><p><b>RESULTS</b>There is a significant association between GSTT1 null genotype with idiopathic azoospermia risk (odds ratio [OR] 2.36, 95% confidence interval [CI] 1.33-4.20, P=0.003) or idiopathic oligospermia risk (OR 2.00, 95% CI 1.17-3.27, P=0.010).</p><p><b>CONCLUSION</b>GSTT1 null genotype is a predisposing risk factor for sporadic idiopathic azoospermia or oligospermia in northwestern China.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Oligospermie
/
Polymorphisme génétique
/
Mobilité des spermatozoïdes
/
Études cas-témoins
/
Chine
/
Réaction de polymérisation en chaîne
/
Facteurs de risque
/
Prédisposition génétique à une maladie
/
Azoospermie
/
Génétique
Type d'étude:
Etude d'étiologie
/
Étude observationnelle
/
Étude pronostique
Limites du sujet:
Adulte
/
Humains
/
Mâle
Pays comme sujet:
Asie
langue:
Anglais
Texte intégral:
Asian Journal of Andrology
Année:
2008
Type:
Article
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