Endothelium-specific gene and stem cell-based therapy for erectile dysfunction / 亚洲男科学杂志(英文版)
Asian Journal of Andrology
;
(6): 14-22, 2008.
Article
Dans Anglais
| WPRIM
| ID: wpr-360008
ABSTRACT
Erectile dysfunction (ED) commonly results from endothelial dysfunction of the systemic vasculature. Although phosphodiesterase type 5 (PDE-5) inhibitors are effective at treating most cases of ED, they must be taken routinely and are ineffectual for a meaningful number of men. In recent years gene and stem cell-based therapies targeted at the penile endothelium have been gaining momentum in preclinical studies. These early studies reveal that gene and stem cell-based therapies may be both enduring and efficacious, and may eventually lead to a cure for ED. The following review will highlight our current understanding of endothelial-specific gene and stem cell-based therapies performed to date in a number of experimental animal models.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Superoxide dismutase
/
Thérapeutique
/
Transplantation
/
Endothélium vasculaire
/
Thérapie génétique
/
Différenciation cellulaire
/
Cellules souches multipotentes
/
Transplantation de cellules souches
/
Cellules endothéliales
/
Facteur de croissance endothéliale vasculaire de type A
Type d'étude:
Étude pronostique
Limites du sujet:
Animaux
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Asian Journal of Andrology
Année:
2008
Type:
Article
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