Regulative effects of Chinese herbs for nourishing yin and removing fire on gene expressions of estrogen receptor alpha, insulin-like growth factor-1 receptor, epithelial growth factor receptor and protein synthesis in epiphyseal growth plate of female pubertal rats / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 721-724, 2008.
Article
Dans Chinois
| WPRIM
| ID: wpr-360588
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of Chinese herbs for nourishing yin and removing fire (NYRF) on gene expressions of estrogen receptor alpha (ER alpha), insulin-like growth factor-1 receptor (IGF-1R) and epithelial growth factor receptor (EGFR) in the epiphyseal growth plate of the female pubertal rats.</p><p><b>METHODS</b>The rats were randomly divided into the control group and the intervened group. Immunohistochemistry and realtime-PCR methods were used to measure the gene expression of ER alpha, IGF-1R and EGFR and their protein synthesis in epiphyseal growth plate.</p><p><b>RESULTS</b>After being intervened with NYRF, the gene expressions of ER alpha and IGF-1R were down-regulated and their protein synthesis markedly reduced, while those of EGFR were unchanged.</p><p><b>CONCLUSION</b>NYRF can modulate the development and maturation of bone by regulating the expressions of ER alpha and IGF-1R in the epiphyseal growth plate.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pharmacologie
/
Biosynthèse des protéines
/
Médicaments issus de plantes chinoises
/
Répartition aléatoire
/
Expression des gènes
/
Yin-yang
/
Récepteur IGF de type 1
/
Rat Sprague-Dawley
/
Récepteur alpha des oestrogènes
/
Modèles animaux de maladie humaine
Type d'étude:
Essai clinique contrôlé
/
Étude pronostique
Limites du sujet:
Animaux
/
Femelle
/
Humains
langue:
Chinois
Texte intégral:
Chinese Journal of Integrated Traditional and Western Medicine
Année:
2008
Type:
Article
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