Evaluation of the immunogenicity of Bordetella bronchiseptica, a vaccine antigen / 대한수의학회지
Korean Journal of Veterinary Research
;
: 75-79, 2014.
Article
Dans Coréen
| WPRIM
| ID: wpr-36076
ABSTRACT
Bordetella (B.) bronchiseptica is a causative agent of swine atrophic rhinitis that promotes colonization of the mucous membrane of the swine nasal cavity by Pasteurella (P.) multocida. Mixed infection with B. bronchiseptica and P. multocida leads to growth inhibition of pigs, resulting in significant economic loss. There are many commercial vaccines for atrophic rhinitis, including B. bronchiseptica as a killed vaccine antigen (Ag). However, the immunogenicity of killed B. bronchiseptica Ag has not yet been elucidated; therefore, this study was conducted to investigate the immunogenicity of killed B. bronchiseptica Ag and the type of immune response it induces. In vitro assays using mouse spleen cells and flow cytometry revealed that B. bronchiseptica Ag induced high proliferation capability of lymphocytes, especially B lymphocytes, and the proliferating cells showed a significant response to interleukin (IL)-2. B. bronchiseptica Ag also enhanced the production of IL-12, a representative cytokine for cell-mediated immunity. In vivo experiments using mice showed that the injection of B. bronchiseptica Ag markedly induced Ag-specific antibody. Taken together, these results indicate that B. bronchiseptica Ag has high immunogenicity by itself.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Rate
/
Suidae
/
Bordetella
/
Vaccins
/
Lymphocytes B
/
Lymphocytes
/
Pasteurella
/
Rhinite atrophique
/
Interleukines
/
Bordetella bronchiseptica
Limites du sujet:
Animaux
langue:
Coréen
Texte intégral:
Korean Journal of Veterinary Research
Année:
2014
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS