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Treatment of paraneoplastic pemphigus with Castleman's disease / 中华外科杂志
Chinese Journal of Surgery ; (12): 849-852, 2004.
Article Dans Chinois | WPRIM | ID: wpr-360948
ABSTRACT
<p><b>OBJECTIVE</b>To discuss the clinical findings and treatment of paraneoplastic pemphigus (PNP) with Castleman's disease.</p><p><b>METHODS</b>To investigate the clinical, histopathologic and CT findings of 8 cases paraneoplastic pemphigus with Castleman's disease.</p><p><b>RESULTS</b>All of 8 patients were diagnosed PNP first and were found Castleman's tumor incidently during routine examination. All 8 cases showed severe erosion or ulcer of the oral mucosa with various skin lesions. Histopathologically, there were intraepidermal acantholytic vesicle, basal cell liquefaction, necrotic keratinocytes in the epidermis and lymphocyte infiltration in the upper dermis. CT scan appeared solitary mass in these patients. Some of them were attacked by bronchiolitis obliterans. All 8 patients were failed by use of predisone. Obvious relief of PNP and pulmonary lesion occurred after tumor was rescted.</p><p><b>CONCLUSIONS</b>Paraneoplastic pemphigus with Castleman's disease is a rare disease. The key step is to find and resect the tumor in abdomen. CT scan should be used to detect the tumor in patients with PNP, especially, when predisone was failed in treatment.</p>
Sujets)
Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Syndromes paranéoplasiques / Thérapeutique / Études rétrospectives / Hyperplasie lymphoïde angiofolliculaire / Pemphigus chronique bénin familial / Association thérapeutique / Diagnostic Type d'étude: Etude diagnostique / Étude observationnelle Limites du sujet: Adolescent / Adulte / Femelle / Humains / Mâle langue: Chinois Texte intégral: Chinese Journal of Surgery Année: 2004 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Syndromes paranéoplasiques / Thérapeutique / Études rétrospectives / Hyperplasie lymphoïde angiofolliculaire / Pemphigus chronique bénin familial / Association thérapeutique / Diagnostic Type d'étude: Etude diagnostique / Étude observationnelle Limites du sujet: Adolescent / Adulte / Femelle / Humains / Mâle langue: Chinois Texte intégral: Chinese Journal of Surgery Année: 2004 Type: Article