Experiment of rhBMP-2 in posterolateral spinal fusion in aged rabbits / 中国骨伤
China Journal of Orthopaedics and Traumatology
;
(12): 28-32, 2010.
Article
Dans Chinois
| WPRIM
| ID: wpr-360998
ABSTRACT
<p><b>OBJECTIVE</b>Posterolateral intertransverse process fusion was performed in aged and young adult female rabbits lumbar spine using recombinant human bone morphogenetic protein-2 (rhBMP-2) and autograft to reveal the function of rhBMP-2 on spinal fusion on aged animals.</p><p><b>METHODS</b>A total of 24 female New Zealand white rabbits included 12 young adult of 6 months and 12 aged of 2-year-old, was divided into 4 groups (1) young adult autologous iliac crest bone group [ICBG(Y), n=6); (2) young adult rhBMP-2/absorbable collagen sponge (ACS) group [BMP-2(Y), n=6]; (3) aged autologous iliac crest bone group [ICBG(O), n=6]; aged rhBMP-2/ACS group [BMP-2(O), n=6]. All were underwent posterolateral fusion in same day. rhBMP-2 and autologous iliac crest bone was implant bilateral LS-L6 intertransverse processes, respectively. Half of the rabbits were sacrificed at 3.6 weeks following surgery, respectively. The results were assessed by manual palpation, radiographs, computed tomographic scans (3D) and histology.</p><p><b>RESULTS</b>Six weeks after surgery, radiography, computed tomography and histology indicated the different result in healing in the posterolateral fusion using rhBMP-2 compared to ICBG (P < 0.05). Aged BMP-2 group showed significantly higher fusion rates than Aged ICBG group.</p><p><b>CONCLUSION</b>This study demonstrated rhBMP-2 can increase the posterolateral fusion rate and new bone quality in aged rabbitss than autograft, it may take the place of ICBG. But its role is effected by age.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Palpation
/
Anatomopathologie
/
Pharmacologie
/
Moelle spinale
/
Arthrodèse vertébrale
/
Chirurgie générale
/
Transplantation
/
Transplantation autologue
/
Protéines recombinantes
/
Vieillissement
Limites du sujet:
Animaux
/
Femelle
/
Humains
langue:
Chinois
Texte intégral:
China Journal of Orthopaedics and Traumatology
Année:
2010
Type:
Article
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