Serum Vascular Endothelial Growth Factor in Hepatocellular Carcinoma / 한국간담췌외과학회지
Korean Journal of Hepato-Biliary-Pancreatic Surgery
;
: 7-12, 2000.
Article
Dans Coréen
| WPRIM
| ID: wpr-36547
ABSTRACT
BACKGROUNDS/AIMS:
Growth of tumors and their metastases is dependent on factors that stimulate vessel formation (angiogenesis). Vascular endothelial growth factor (VEGF) is closely related to angiogenesis in various human cancers. The aim of this study was to determine the value of serum VEGF levels in hepatocellular carcinomas as a tumor marker.METHODS:
We measured serum VEGF levels, by enzyme immunoassay, and platelet counts in healthy controls (n=22), liver cirrhosis (LC; n=4) and hepatocellular carcinomas (HCC; n=14).RESULTS:
The mean serum VEGF levels in controls and the patients with LC and HCC were 251.8+/-121.5 (mean+/-SD), 163.4+/-82.1 and 557.8+/-520.3pg/ml, respectively. The levels were significantly elevated in the HCC group, compared with the control group (p<0.05). Serum VEGF levels in the HCC group were highly correlated with platelet counts (r=0.915, p<0.05).Conclusions:
We consider that serum VEGF is a possible tumor marker for HCC. Serum VEGF may be partly derived from platelets.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Numération des plaquettes
/
Techniques immunoenzymatiques
/
Carcinome hépatocellulaire
/
Facteur de croissance endothéliale vasculaire de type A
/
Cirrhose du foie
/
Métastase tumorale
Limites du sujet:
Humains
langue:
Coréen
Texte intégral:
Korean Journal of Hepato-Biliary-Pancreatic Surgery
Année:
2000
Type:
Article
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