Effect of Low-dose Aprotinin on Reduction in Blood Loss in Coronary Artery Bypass Grafting / 日本心臓血管外科学会雑誌

ABSTRACT

Twenty patients undergoing primary elective coronary artery bypass grafting were randomly divided into two groups to evaluate the hemostatic effect of aprotinin. Low dose aprotinin (1×10⁶KIU) was used during cardiopulmonary bypass in one group (11 patients), and the others were not given any. There was no need for reoperation due to bleeding and no difference of graft patency in the two groups. Changes in platelet, fibrinogen, thromboxane B₂ and antiplasmin values were similar in both groups. Postoperative blood loss was significantly lower in the aprotinin treated patiens (<i>p</i><0.05) and postoperative blood use was also significantly lower (<i>p</i><0.01). We conclude that low-dose aprotinin had a beneficial effect for reducing postoperative blood loss and blood use, though we did not find any changes in the results of laboratory tests.