Coronary Artery Bypass Operation for a Patient with Anti-drug Antibody / 日本心臓血管外科学会雑誌

ABSTRACT

We report an alternative way to preserve autologous blood with the aid of erythropoietin for a patient with anemia combined with irregular antibody who need the CABG operation. A 62-year-old woman was given a diagnosis of angina pectoris due to three-vessel coronary artery disease. All blood reserved for the coronary operation was incompatible on the crossmatch test and an irregular antibody was suspected. Antibody screening tests revealed anti-drug antibody and anti-P1 antibody. The operation was postponed because she had anemia. After 800ml of autologous blood was collected with administration of erythropoietin and iron for a month, the operation was performed. Two saphenous vein grafts were anastomosed to the left anterior descending artery and circumflex branch respectively. Total blood loss was 580g. Her postoperative course was uneventful and hemoglobin level was ranged from 7 to 10g/dl without any homologous blood transfusion.