Incidences and Prognostic Impact of c-KIT, WT1, CEBPA, and CBL Mutations, and Mutations Associated With Epigenetic Modification in Core Binding Factor Acute Myeloid Leukemia: A Multicenter Study in a Korean Population
Annals of Laboratory Medicine
; : 288-297, 2015.
Article
de En
| WPRIM
| ID: wpr-36811
Bibliothèque responsable:
WPRO
ABSTRACT
BACKGROUND: To identify potential molecular prognostic markers in core binding factor (CBF) AML, we analyzed incidences and prognostic impacts of mutations in c-KIT, WT1, CEBPA, CBL, and a number of epigenetic genes in CBF AML. METHODS: Seventy one and 21 AML patients with t(8;21) and inv(16) were enrolled in this study, respectively. NPM1, CEBPA, c-KIT, IDH1/2, DNMT3A, EZH2, WT1, and CBL mutations were analyzed by direct sequencing. Patients were categorized with respect to c-KIT and WT1 mutation status, and both clinical features and prognoses were compared. RESULTS: The incidences of FLT3 internal tandem duplication (ITD), NPM1, CEBPA, IDH1/2, DNMT3A, EZH2, and CBL mutations were low (< or =5%) in CBF AML patients. However, c-KIT and WT1 mutations occurred frequently (10.9% and 13.8%, respectively). t(8;21) patients with c-KIT mutations showed significantly shorter overall survival (OS) and disease free survival (DFS) periods than those without mutations (P<0.001, for both); however, although the limited number of t(8;21) patients were analyzed, WT1 mutation status did not affect prognosis significantly. Relapse or death during follow-up occurred more frequently in t(8;21) patients carrying c-KIT mutations than in those without the mutation, although the difference was significant only in a specific patient subgroup with no WT1 mutations (P=0.014). CONCLUSIONS: The incidences of mutations in epigenetic genes are very low in CBF AML; however, c-KIT and WT1 mutations occur more frequently than others. The poor prognostic impact of c-KIT mutation in t(8;21) AML patients only applies in a specific patient subgroup without WT1 mutations. The prognostic impact of WT1 mutation in CBF AML is not evident and further investigation is required.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Pronostic
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Translocation génétique
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Leucémie aigüe myéloïde
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Incidence
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Taux de survie
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Survie sans rechute
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Protéines proto-oncogènes c-kit
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Protéines liant les séquences stimulatrices de type CCAAT
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Protéines WT1
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Épigenèse génétique
Type d'étude:
Clinical_trials
/
Incidence_studies
/
Prognostic_studies
Limites du sujet:
Adolescent
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Adult
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Aged
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Aged80
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Child
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Female
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Humans
/
Male
Pays comme sujet:
Asia
langue:
En
Texte intégral:
Annals of Laboratory Medicine
Année:
2015
Type:
Article