Association between Mitochondrial D-loop Polymorphism and Copy Number / 체질인류학회지
Korean Journal of Physical Anthropology
;
: 131-136, 2014.
Article
Dans Coréen
| WPRIM
| ID: wpr-36946
ABSTRACT
Mitochondria in cancer have genetic instability like genetic mutations or polymorphisms, and D-loop is hot spot region and is suggested its association with cancer prognosis. Genetic variations of D-loop were associated with mitochondrial copy number. In present study, mitochondrial polymorphism in D-loop (D310 and D514) was studied in 108 DNAs from health individuals and its association with mitochondrial copy number was also investigated. In D310 polymorphism, C7 was most common (37.7%, 40/108), and C8 and C9 was found in 32.1% and 30.2%, respectively. In D514 polymorphism, (CA)5 and (CA)4 was shown in 61.4% and 38.6%, respectively. Mitochondrial copy number was increased in 40.7% while it was decreased in 59.3%. There was no association between mitochondrial polymorphism and copy number. Follow-up study should be needed to confirm its change in same individuals.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pronostic
/
Variation génétique
/
ADN
/
Mitochondries
Type d'étude:
Étude observationnelle
/
Étude pronostique
langue:
Coréen
Texte intégral:
Korean Journal of Physical Anthropology
Année:
2014
Type:
Article
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