Expression of Cyclooxygenase-2 and Embryonic Lethal Abnormal Vision-Like Protein HuR in Gallbladder Carcinoma
Korean Journal of Pathology
;
: 42-47, 2010.
Article
Dans Anglais
| WPRIM
| ID: wpr-37350
ABSTRACT
BACKGROUND:
Cyclooxygenase-2 (COX-2) is an enzyme that promotes proliferation of tumor cells. HuR is a member of the family of embryonic lethal abnormal vision-like proteins. Recent studies show that cytoplasmic HuR stabilizes the mRNA of COX-2 and regulates the expression of COX-2. Moreover, cytoplasmic HuR expression is associated with a poorer prognosis for patients with some cancers. The aim of this study was to investigate the expression patterns of and the relationship between COX-2 and HuR in gallbladder carcinoma.METHODS:
We analyzed COX-2 and HuR expression by immunohistochemical staining of 108 gallbladder carcinomas.RESULTS:
COX-2 expression and nuclear and cytoplasmic HuR expression were seen in, respectively, 61 (56.5%), 77 (71.3%), and 4 (3.7%) cases. COX-2 and nuclear HuR were simultaneously expressed in 44 of the 108 samples without any quantitative association between the levels of each. COX-2 expression correlated with tumor stage, differentiation (based on histology), lymph node metastasis, perineural invasion, and survival. Nuclear and cytological expression of HuR did not correlate with any clinical parameters.CONCLUSIONS:
COX-2 expression but not HuR may play an important role in the prognosis of patients with gallbladder carcinoma.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pronostic
/
ARN messager
/
Protéines
/
Cytoplasme
/
Cyclooxygenase 2
/
Antigènes Hu de l'encéphalomyélite paranéoplasique
/
Protéine-1 similaire à ELAV
/
Vésicule biliaire
/
Tumeurs de la vésicule biliaire
/
Noeuds lymphatiques
Type d'étude:
Étude pronostique
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Korean Journal of Pathology
Année:
2010
Type:
Article
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