Focal Segmental Glomerular Sclerosis: Effects of Steroids and Prognosis. A Retrospective Study in 30 Patients / 日本農村医学会雑誌

ABSTRACT

We performed a retrospective study of the effects of steroids and the factors that deteriorate renal function in 30 patients with primary focal segmental glomerular sclerosis. The mean observation periods from the onset of proteinuria and from the histological diagnosis by renal biopsy were 6.1 ± 5.0 years and 3.9 ± 3.01 respectively. 87% of the patients had been recerving steroid therapy with or without other drugs. In this study, the patients were divided into 3 groups by the initial dose of steroids. A multivariate analysis was performed on the laboratory findings of the 3 groups. In a short-term observation, there were no significant defferences among the groups. However, in a long-term observation (more than one year) it was clarified that the patients who had been given high doses of steroids tend to maintain their renal functoin. We also found that the patients responding to steroids showed a significantly better prognosis than steroid-resistant patients upon examination their nephrotic status and renal functoin.<BR>This statistical analysis confirmed that the factors deteriorating the renal function are hypertension and hyperlipidemia.<BR>In addition, it was revealed that hyperuricemia, is responsible for the renal dissease, failure?