Clinical Evaluation of Oxidative Stress after Taking Jidabokuippo / 日本東洋医学雑誌

ABSTRACT

We measured the level of derivatives of reactive oxygen metabolites (d-ROMs test) and total antioxidant capacity (OXY-adsorbent test) in adult volunteers and assessed whether jidabokuippo affects the oxidative stress regulation system. Twenty subjects received jidabokuippo 7.5 g/day, and the d-ROMs test and the OXY-adsorbent test were carried out 72 hours after taking the study drug. The subjects were also assigned to one of two groups a Favorable response group (n = 6) or a Non-favorable response group (n = 14). The Favorable response group had improvement of such signs and symptoms as stiff shoulders, constipation, and bruises.No significant difference was observed in the d-ROMs test.However, the OXY-adsorbent test at 72 h was significantly lower than that at the pre-administration (p = 0.0290). No significant differences were observed in either the d-ROMs test or the OXY-adsorbent test in the favorable response group. On the other hand, the d-ROMs test and the OXY-adsorbent test at 72 h were significantly lower than those at pre-administration in the non-favorable response group (p = 0.0279, p = 0.0413, respectively). These results indicate that jidabokuippo affects the oxidative stress regulation system in human.