Safety of Excessive Intake of <i>Ashitaba</i> Green Juice in Normal and Borderline Mildly Diabetic Subjects / 日本補完代替医療学会誌

ABSTRACT

<b>Objective</b> “<i>Ashitaba</i>” (<i>Angelica keiskei</i>) is a traditional vegetable peculiar to Japan. <i>Ashitaba</i> contains vitamins, dietary fiber and polyphenols such as chalcones abundantly. We previously reported anti-diabetic action of <i>Ashitaba </i>in an animal model as well as in diabetics. In this study, we evaluated the safety of<i> Ashitaba</i> green juice in healthy and borderline mildly diabetic subjects.<br> <b>Methods</b> Japanese adult subjects (n = 24) ingested <i>Ashitaba</i> green juice (31.5 g granulated powder) for 4 weeks. For evaluation of safety, blood chemistry analysis, hematological analysis and urinalysis were conducted.<br> <b>Result</b> On excessive ingestion of <i>Ashitaba</i> green juice for 4 weeks, there were no adverse clinical changes in blood analysis and urinary analysis and no serious symptom was observed.<br> <b>Conclusion</b> These results indicate that excessive ingestion of <i>Ashitaba</i> green juice is safe in healthy and borderline mildly diabetic subjects.<br>