Safety Evaluation of Methoxyflavones Mixture (Ⅰ)from <i>Kempferia parviflora</i>; 28-day Repeated Dose Oral Toxicity Test and Mouse Micronucleus Test / 日本補完代替医療学会誌
Japanese Journal of Complementary and Alternative Medicine
;
: 79-85, 2015.
Article
Dans Japonais
| WPRIM
| ID: wpr-377324
ABSTRACT
Kaempferia parviflora rhizome is used in traditional folk medicines for the treatments of various symptoms in Thailand since ancient times. Several types of methoxyflavones were identified from that plant and the functions of some of those were reported. We determined that five kinds of methoxyflavones (5-hydroxy-3,7,3’,4’-tetramethoxyflavone, 5-hydroxy-7-methoxyflavone, 5-hydroxy-3,7-dimethoxyflavone, 5-hydroxy-3,7,4’-trimethoxyflavone, 5-hydroxy-7,4’-dimethoxyflavone) were included the following treatments of K. parviflora rhizome. The 80 %ethanol extract of that were adsorbed resin, removed 70 % ethanol elution and the rest adsorbed materials were eluted with 99.5 % ethanol. The safety of that five methoxyflavones mixture was evaluated. We performed a 28-day repeated dose of oral toxicity test and a mouse micronucleus test. The former results showed no significant toxicity on body weight, blood analyses, organ weight, blood biochemical analyses. The latter results showed negative, believed that the sample has no mutagenicity for living bodies.
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Indice:
WPRIM (Pacifique occidental)
langue:
Japonais
Texte intégral:
Japanese Journal of Complementary and Alternative Medicine
Année:
2015
Type:
Article
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