Study on risk factors of gastric cancer in Wuwei city of Gansu province / 肿瘤研究与临床

ABSTRACT

Objective The incidence of gastric carcinoma(GC) has significantly difference in different areas because it has different cancerogenic and stimulative factors in different areas. Through displaying the epidemic factors of popular GC in Wuwei city, it can supply etiological clue of the first-level prevention to GC. Methods The research methods about epidemiology of migrant were used to investigate the case fatality rate of GC about the people in Qitai county of Xinjiang province who immigrated from Wuwei. According to the information of GC-death registered, we fitted local cluster analyse with Possion-distribution model, and then the results were processed with case-control study of chi square test; Binomial distribution (p+q)n model was used to familial cluster analysis, and the statistical method of X2 was used to compare the difference between the actual incidence and theoretical incidence of GC. Adopting the history arrangement analysis, the canceration of four precancerous diseases were observed. Nitrogen content of nitrate and nitrite in drinking water were respectively measured by using ultraviolet spectrophotometric and hydrochloride naphthaline ethylenediamine methods. Results The death rates of GC of the first-generation and their descendants of emigrants were much lower than those contemporary beings in Wuwei, but were higher than those contemporary beings in Qitai country. The prevalence of GC had region and familial aggregation. The year canceration proportion of people who had precancerous diseases such as stomach polypus, atrophyic gastritis,gastric ulcer, and remnant stomach were 0.459 %, 0.431%, 0.381% and 0.178 % respectively. The percentage of crowd attributive risk were 41.26 %, 29.35 %, 4.68 % and 3.39 % respectively. Nitrogen contents of nitrate and nitrite either in surface water or in shallow water were significantly higher in Wuwei city than that in Lanzhou city (P＜0.01). Conclusion Death rates of GC for the emigrants of the first-generation and their descendants are much lower than their ancestry, but higher than those of the generation in Qitai county. The prevalence of GC has region and familial aggregation. It is the immanent factor of popular GC in Wuwei City that there are higher contents of nitrogen content of nitrate and nitrite in residenter' s drinking water and four precancerous diseases including stomach polypus, atrophyic gastritis, gastric ulcer,and remnant stomach.