Effects of aprotinin on the inflammatory response induced by cardiopulmonary bypass / 中华胸心血管外科杂志
Chinese Journal of Thoracic and Cardiovascular Surgery
;
(12): 25-26, 2001.
Article
Dans Chinois
| WPRIM
| ID: wpr-384154
ABSTRACT
Objective:
To observe the effects of high-dose aprotinin and low-dose aprotinin on the inflammatory response induced by cardiopulmonary bypass (CPB).Methods:
Thirty-two patients who underwent heart valve replacement were randomized in double-blind fashion into three groups control group (n=6), low-dose group (n=13) and high-dose group (n=13). Blood samples were taken from radial artery at three times intervals before CPB, at the end of CPB and 2 hours after termination of CPB. Neutrophil CD11b integrin expression, plasma level of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were measured.Results:
The high-dose group demonstrated no significant change in neutrophil CD11b expression and in plasma level of TNF-α, but a significant decrease in plasma level of IL-6. However, the low-dose group only demonstrated a lower CD11b expression and a lower TNF-α level at 2 h after CPB termination.Conclusion:
Aprotinin has a dose-reponse effect. High-dose aprotinin is more effective in the reduction of inflammatory response induced by cardiopulmonary bypass.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Type d'étude:
Essai clinique contrôlé
langue:
Chinois
Texte intégral:
Chinese Journal of Thoracic and Cardiovascular Surgery
Année:
2001
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS