Current research status of TOP2A gene with response to anthracycline-based chemotherapeutic agents in breast cancer / 国际肿瘤学杂志

ABSTRACT

Anthracycline-based chemotherapeutic agents were extensively applied to the treatment of breast cancer. The relation of its response to TOP2A gene was proved by a number of clinical studies demonstrating that patients with both HER2 gene amplification and TOP2A gene aberration have a favored outcome,but a consensus was not yet achieved.