Relationships among the expression of VEGF, MMP-2 , MMP-9 and metastasis in breast carcinoma / 中国医师杂志
Journal of Chinese Physician
;
(12): 1490-1493, 2010.
Article
Dans Chinois
| WPRIM
| ID: wpr-385488
ABSTRACT
Objective To study the expression of VEGF, MMP-2 and MMP-9 in benign and malignant lesions of breast and their effects on breast carcinoma's invasiveness and metastasis. Methods VEGF,MMP-2 and MMP-9 expression was detected by SP method in 20 breast fibroadenoma and 12 normal breast specimens taken from non-cancerous regions adjacent to breast cancer tissue and 38 breast carcinomas. Results The expression rate of VEGF, MMP-2 and MMP-9 in breast carcinoma was remarkably higher than those in normal breast tissue and breast fibrogdenoma (63.2% vs 25.0% and 30. 0% ,78. 95% vs 33.3% and 35.0% and 71.1% vs 41.7% and 45.0% ,respectively; P <0.05). There was a correlation between VEGF, MMP-2 and MMP-9 expression and nodal metastasis ( P <0.05). High expression of VEGF, MMP-2 and MMP-9 was correlated with pathological grade ( P < 0.05, respectively). The overexpression of VEGF was related with those of MMP-2 and MMP-9 in breast cancer( VEGF and MMP-2rs =0.541, P <0.01 ;VEGF and M M P-9 rs = 0.11, P < 0.01; MMP-2and M MP-9 rs= 0P < 0.01 ). Conclusion VEGF,MMP-2 and MMP-9 overexpression is strongly related to the invasiveness and metastasis of breast carcinoma, which might be valuable in evaluating tumor invasion and metastasis.
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Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Journal of Chinese Physician
Année:
2010
Type:
Article
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