Effect observation on sodium aescinate for injection combined with percutaneous laser disc decompression in treating lumbar disc herniation / 中国医师进修杂志

ABSTRACT

Objective To study the therapeutic effect of sodium aescinate for injection combined with percutaneous laser disc decompression (PLDD) in treating lumbar disc herniation (LDH). Methods Ninety-eight cases of LDH were divided into 2 groups by means of random number table treating group and control group, 49 cases in each group. The treating group were given the treatment of sodium aescinate for injection after received PLDD,the control group were given mannitol for injection after received PLDD. The operation evaluation criteria of lumbago and backache of Chinese medical association spine group was taken to value the therapeutic effect at 7 days, 1 month, 3 months and 6 months postoperation. At the same time,C-reactive protein (CRP) content in serum were measured at preoperation and 1, 3, 7 days postoperation.Results At 7 days postoperation, the excellent and good rate of the treating group was significantly higher than that of the control group[93.9%(46/49) vs. 55.1%(27/49),P ＜ 0.01], at 1, 3 and 6 months postoperation,the excellent and good rate had no statistically significant between the two groups (P ＞0.05). At 3 days postoperation, the serum CRP content in the treating group [(13.0 ± 2.2) mg/L] was lower than that of the control group [(31.0 ± 5.3) mg/L], there were significant differences between the two groups (P ＜ 0.01).Conclusions Sodium aescinate for injection combined with PLDD can control postoperative inflammation reaction effectively, improve the therapeutic effect. Therefore it should be a valid method in treating LDH.