Studies on the effect of CMPS on acute fatty liver induced by DL-E / 国际中医中药杂志

ABSTRACT

Objective To study the effect of CMPS on acute fatty liver induced by DL-E. Methods Oral administration DL-E (250 mg/kg) was given to mice to establish the models of acute fatty liver mice. Liver index, the contents of TG and morphological changes of liver tissue were detected to study the effect of CMPS on liver fat accumulation.Results The Liver index and the contents of TG in the model group rose. Under light microscope, lobular central vein could be seen around the liver steatosis and cytoplasm of liver cells appeared vacuolated changes. As compared with the model group, indexes significantly improved in CMPS group. Conclusion DL-E could obviously damage the liver and lead to liver fat accumulation. CMPS has protective effect on liver injury.