Effect of all-trans retinoic acid on the expression of matrix metalloproteinases-9 in perihematomal brain tissue after intracerebral hemorrhage in rats / 国际脑血管病杂志
International Journal of Cerebrovascular Diseases
;
(12): 499-502, 2010.
Article
Dans Chinois
| WPRIM
| ID: wpr-387551
ABSTRACT
Objective To investigate the effect of all-trans retinoic acid (ATRA) on the expression of matrix metalloproteinases-9 (MMP-9) in perihematomal brain tissue after intracerebral hemorrhage in rats.Methods Forty Sprague-Dawley rats were randomly allocated into ATRA and normal saline control groups.Each group was redivided into 2 h,48 h,72 h,and 7 d subgroups (n = 5 in each subgroup).The autologous blood was injected into the rat caudate nucleus for establishing a model of intracerebral hemorrhage under the guidance of stereotaxic apparatus.Intraperitoneal ATRA (1 mg/d) and the same volume of saline were injected respectively after the success of modeling.The expression of MMP-9 at different time points was detected by using immunohistochemical staining.Results The expression of MMP-9 in microvascular endothelial cells in perihematomal brain tissue in rats was upregulated 24 h after intracerebral hemorrhage in the ATRA and normal saline control groups,and it reached the peak at 48 to 72 h.The expression of MMP-9 in the ATRA group at different time points was lower than that in the normal saline control group (all P<0.05).Conclusions ATRA inhibits the expression of MMP-9 in perihematomal brain tissue after intracerebral hemorrhage in rats,and thus may reduce the brain edema.
Texte intégral:
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Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
International Journal of Cerebrovascular Diseases
Année:
2010
Type:
Article
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