Pancreatic stellate cells:role in pancreatic cancer / 国际外科学杂志

ABSTRACT

Pancreatic cancer is a frequent malignant tumor in digestive tract with extremely poor prognosis,characterized by difficult early diagnosis,high malignancy,poor resective,limited response to chemotherapy and radiotherapy and an intense fibrotic reaction known as tumor desmoplasia.Pancreatic stellate cells play an important role in this reaction and can stimulate pancreatic cancer cells proliferation,invasion and metastasis through the interaction with pancreatic cancer cells.This review describes the role of pancreatic stellate cells in the process of pancreatic cancer progression.