Advance in the ACTH therapeutic mechanisms of infantile spasms / 国际儿科学杂志

ABSTRACT

Infantile spasms is a severe and refractory epileptic encephalopathy that occurs in infancy and early childhood.Adrenocorticotropic hormone (ACTH) has been the major therapy for infantile spasms.However,the ACTH therapeutic mechanisms of infantile spasms still lack relatively reasonal explaination.Recent researches has been found that ACTH might produce its herapeutic effect by suppression of excessive secretion and releasing of corticotrophin releasing hormone,modulation of production and releasing of neurosteroids,neurotrophins,and other putative pathways.