The relation of forkhead box gene and growth / 国际儿科学杂志

ABSTRACT

Forkhead box(Fox) proteins characterized by a conserved winged-helix DNA binding domain constitute a large family of transcription factors.Fox proteins regulate the gene transcription not only by recruiting various coactivators like most transcription factors,but also by binding to the condensed chromosomes directly,which can remodel chromatin structure and generate a combinatorial effect with other transcription factors to cause significant changes in expression.The diverse biological processes that Fox proteins influence,such as embryonic development,aging and immunoregulation,have also been covered in this article.