Neuroprotective mechanisms of histone deacetylase inhibitors in ischemic stroke / 国际脑血管病杂志
International Journal of Cerebrovascular Diseases
; (12): 358-362, 2010.
Article
de Zh
| WPRIM
| ID: wpr-389099
Bibliothèque responsable:
WPRO
ABSTRACT
Histone deacetylases (HDACs) catalyze the deacetylation of histone and nonhistone proteins. They play important roles in regulating chromatin remodeling and gene transcription,and that aberrant chromatin remodeling and transcriptional dysregulation are associated with many neurodegenerative diseases. Preclinical studies have suggested that histone deacetylases inhibitors (HDACIs) can target diverse pathophysiologies of ischemic stroke,not only reduce neuronal damage and infarct volume,but also promote the neuronal plasticity and functional recovery after ischemia. This article mainly reviews the neuroprotective mechanisms of HDACIs in ischemic stroke.
Texte intégral:
1
Indice:
WPRIM
langue:
Zh
Texte intégral:
International Journal of Cerebrovascular Diseases
Année:
2010
Type:
Article