The present understanding of serine proteinase inhibitor-9 / 国际外科学杂志
International Journal of Surgery
; (12): 404-407, 2010.
Article
de Zh
| WPRIM
| ID: wpr-389410
Bibliothèque responsable:
WPRO
ABSTRACT
Serine proteinase inhibitor9(P1-9),a charac-teristic member of serpins,has been identified as the only inhibitor of granzyme B(GrB).Accumulated evidence suggested that PI-9 inhibits GrB-induced apoptosis by blocking DNA fragmentation of target cell.Physiologically,PI-9 could protect cytotoxic lymphocytes from committing autolysis or fratricide,and play an important role in facilitating immunologic tolerance of immune-privileged sites.In addition,evidences in recent years suggest that PI-9 Was also involved in vailous pathologic processes,such as inflammation,trans plantation and immune tolerance of tumor.
Texte intégral:
1
Indice:
WPRIM
Type d'étude:
Prognostic_studies
langue:
Zh
Texte intégral:
International Journal of Surgery
Année:
2010
Type:
Article