Advances in the study of microRNA-143 in tumorigenesis / 国际肿瘤学杂志

ABSTRACT

MicroRNA-143(miR-143)is a non-coding small RNA composed of approximate 22 nuelcotides,participating in post-transcription gene regulation. MiR-143 is lowly expressed in many human cancer cells. Recent studies show that miR-143 is involved in cell differentiation ,proliferation and apoptosis,closely related to tumorigenesis. Extracellular signal-regulated kinase 5 (ERK5), fibronectin type Ⅲ domain containing 3B(FNDC3B) ,DNA methyltranferase 3A(DNMT3A) ,and K-ras are putative targets of miR-143. MiR-143 plays a role in the mechanism of tumor growth, invasion, metastasis, and drug resistance by regulating target genes. Furthermore,the combining therapy of miR-143 and antitumor drug will open a novel approach for the treatment of tumor.