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Effects of rosiglitazone on the atherosclerosis and oxidative stress in diabetic rabbits / 中华内分泌代谢杂志
Chinese Journal of Endocrinology and Metabolism ; (12): 17-18, 2010.
Article Dans Chinois | WPRIM | ID: wpr-391556
ABSTRACT
Rosiglitazone was used for intervention of atherosclerosis in diabetic rabbits.The results showed that the intima/medium thickness ratio,cross section area of plaque,and the expressions of NADPH oxidase p22phox,gp91 phox were decreased;while the total anti-oxidative ability was increased after administration of rosiglitazone as compared with the non-intervention group(all P<0.05).Compared with rosiglitazone treatment group,serum hepatocuprein leveI in rosiglitazone prevention group was increased,while serum malonaldehyde level decreased(both P<0.05).This study suggests that rosiglitazone may have the effect of reducing the oxidative stress and the formation of atherosclerotic plaque in diabetics.

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) langue: Chinois Texte intégral: Chinese Journal of Endocrinology and Metabolism Année: 2010 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) langue: Chinois Texte intégral: Chinese Journal of Endocrinology and Metabolism Année: 2010 Type: Article