Expression and significance of nuclear factor-kappa B and proliferating cell nuclear antigen in uterine cervix cancer tissues / 中国基层医药
Chinese Journal of Primary Medicine and Pharmacy
;
(12): 1353-1354, 2009.
Article
Dans Chinois
| WPRIM
| ID: wpr-393224
ABSTRACT
Objective To study the expression and significance of nuclear factor-kappa B(NF-κB)and proliferating cell nuclear antigen(PCNA)in uterine cervix cancer tissues.Methods The expression of NF-κB p65 and PCNA in the uterine cervix cancer tissues(n=45)and normal cervix tissues(n=30)were detected by immunohisto chemistry method.Results The expression rate of NF-κB p65 and PCNA in the uterine cervix cancer tissues were significantly higher than that in normal cervix tissues(P<0.05).The expression of NF-κB p65 and PCNA in stage Ⅰ b,Ⅱa were significantly higher than that in stageⅠ a(P<0.05),they were significantly higher in poorly differentiated than those in moderately differentiated,well-differentiated(P < 0.05),they were significantly higher in existing lymphnode metastasis than those in non-existing lymphnode metastasis(P <0.05);and the expression of NF-κB p65 was positively related to PCNA in uterine cervix cancer tissues(r=0.705,P<0.05).Conclusion The invasion,infestation and metastasis maybe dosely related to NF-κB and PCNA.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Chinese Journal of Primary Medicine and Pharmacy
Année:
2009
Type:
Article
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