RASSF1 gene in human tumour / 国际外科学杂志

ABSTRACT

A series of gene function devitalized increase gradually because of tumnr-suppressing gene endogenous deactivation while not classic mutation or absence. Unlike mutation devitalizalion, methylation devitalization is reversible.Gene silencing because of high methylation of promoter has many potential clinical uses.For example, it's in favor of early diagnosis, prognosis and therapy of tumors such as lung caneer, breast cancer,renal cancer, gastric cancer, bladder cancer and so on. RASSF1A belongs to the gene thatalways due to methylation deactivation not mutation deactivation. And this gene is similar to Ras receptor of mammalian. RASSF1A suppressed tumor growth in vivo and in vitro. This further supports it could be one tumor-suppressing gene. It plays an important role in cell cycle regulation, apoptosis, and micropipe stabilization. This review mainly summarizes information and advancement about RASSF1A tumor-suppressing gene in genetic structure, endogenous gene inactivation, and functional analysis.