A Case of Intestinal Behcet's Disease Complicated Enterocutanous Fistula with a Good Response to Adalimumab
Journal of Rheumatic Diseases
;
: 147-151, 2012.
Article
Dans Coréen
| WPRIM
| ID: wpr-39662
ABSTRACT
Behcet's disease (BD) is a multisystemic disorder, which is characterized by recurrent oral aphthous ulcers, genital ulcers, uveitis, and skin lesion. Although intestinal involvement is an uncommon manifestation of the BD, it leads to a poor prognosis, as a result of a high complication, such as intestinal perforation, fistula formation, and massive hemorrhage. Intestinal BD has the tendency for the resistance to conventional medical treatment, and it often requires a surgical intervention because of severe complication. Although the causes of intestinal BD are unknown, some studies show that tumor necrosis factor Alpha (TNF-alpha) plays a key role in the pathogenesis of BD. Therefore, anti-TNF-alpha monoclonal antibody, such as adalimumab, is one of the useful treatment for refractory and relapsed intestinal BD. We describe a patient who had intestinal BD complicated enterocutanous fistula with a good response to adalimumab.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pronostic
/
Peau
/
Stomatite aphteuse
/
Ulcère
/
Uvéite
/
Facteur de nécrose tumorale alpha
/
Anticorps monoclonaux humanisés
/
Fistule
/
Adalimumab
/
Hémorragie
Type d'étude:
Étude pronostique
Limites du sujet:
Humains
langue:
Coréen
Texte intégral:
Journal of Rheumatic Diseases
Année:
2012
Type:
Article
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