Clinical study on the relationship of the expressions of proliferating cell nuclear antigen and endocranium invasion in the convex meningiomas / 中国医师进修杂志

ABSTRACT

Objective To evaluate the relationship of the expressions of proliferating cell nuclear antigen (PCNA) and endocranium invasion in the convex meningiomas.Methods Convex meningioma Simpson I level excises 51 patients were selected.The dural mater 15 mm around the rumors was resected,stochastically divided into four sections (0-1 mm,2-5 mm,6-10 mm,＞10 mm)for pathological inspection.Analysed statistically the study results based on microscopic observation of the HE staining slides and immunohistochemistry of proliferating cell nuclear antigen(PCNA).Results PCNA LI of the group with the endocranium invasion was 10.32±6.74,the other was 2.16±4.93.The atypical meningioma had a high endocranium invasion degree.Conclusion Pathologic grading of meningioma and the expressions of PCNA by immunohistochemical staining method are the factors affecting endoeranium invasion of the convex meningiomas.