Functions of DNA methyltransferase and methylation in tumor generation / 国际外科学杂志

ABSTRACT

Adjustment of epigenetics is closely related with transfer modulation of tumor-related genes. DNA methylation is one of the significant functions of modulation of genetic epigenetics. Abnormal DNA methylation is intensively involved in generation and development of tumor while DNA methylation is cata- lyzed and maintained by DNA methyltransferase(DNMT). So profound study on funetions of DNMT is of great significance to realize generation of abnormal methylation and functions of abnormal methylation in tumor generation and development.