Application of p53 gene therapy for malignant lymphoma / 国际肿瘤学杂志

ABSTRACT

In majority of malignant lymphoma patients the overexpression of mutant p53 gene can be found,and experiments show that p53 gene and the genesis currence and development of malignant lymphoma are closely related.Thus,normal p53 gene carried by recombinant adenovirus vector into tumor cells and its stable expression will play a theraputic role in the treatment of malignant lymphoma.This has been confirmed by the basic research.