Expression of multidrug resistance-related proteins MRP1/LRP/GST-π in carcinoma of the gallbladder and cholangiocarcinoma / 中华普通外科杂志
Chinese Journal of General Surgery
;
(12): 356-359, 2008.
Article
Dans Chinois
| WPRIM
| ID: wpr-400618
ABSTRACT
Objective To investigate the expression of muhidrug resistance-related protein 1 (MRP1),lung resistance-related protein(LfuP)and glutathione S-transferase-π(GST-π)in carcinoma of the gallbladder and cholangiocarcinoma. Methoils MRP1,LRP,GST-πwere measured in experimental group(18 cases of carcinoma of the gallbladder,36 CSSeS Of cholangiocarcinoma)and control group(13cases of cholecystitis and cholangeitis)by immunohistochemistry.Statistical analysis used chi-square test and spearman test. Results The positive rate of MRP1,LRP,GST-π in carcinoma of the gallbladder and eholangiocarcinoma were 72%(13/18),78%(14/18),61%(11/18)and 86%(31/36),75%(27/36),69%(25/36),respectively,significantly higher than those of 23%(3/13),23%(3/13),23%(3/13)(X2=4.5,P<0.05)in control group.The expression of LRP[93%(13/14)]in pafients>60 years old was significantly higher than 64%(14/22)in patients younger than 60 yrs old(x2=3.9,P <0.05).In addition,their expression was not related to gender,age,staging,tumor differentiation and lymph node metastasis(P>0.05).The expression of MRP1 was related with tllose Of GST-π,Spearman correlation coefficient=0.569(P<0.05).Conclusions MRP1,LRP,GsT-π were over expressed in various degrees in carcinoma Of the gallbladder and cholangiocarcinoma witllout chemotherapy.and related to the primary muhidrug resistance Of cholangiocarcinoma and carcinoma of the gallbladder.
Texte intégral:
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Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Chinese Journal of General Surgery
Année:
2008
Type:
Article
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