Expression of HIF-1α and VEGF in synovium of knee joint in adjuvant-induce-arthritis rat / 中国免疫学杂志
Chinese Journal of Immunology
;
(12): 360-362, 2010.
Article
Dans Chinois
| WPRIM
| ID: wpr-402733
ABSTRACT
Objective:
To investigate the expression of HIF-1 and VEGF and the correlation with pathological score of synovium in adjuvant-induce-arthritis rat knee joint.Methods:
Models of adjuvant arthritis(AA)in rats were made successfully, the arthral pathological score was calculated, production of HIF-1α and VEGF protein was assayed by histoimmunchemical staining at different stage after CFA inoculation.Results:
The HIF-1α and VEGF concentration in experimental group were higher than that in control group, and there was significant difference (P<0.01).And correlation between them was significantly(P<0.01), similar with pathological score of synovium(P<0.01).Conclusion:
HIF-1α and VEGF play important roles in the development and progression of synovium of knee joint in AA rat.The interaction of them promote development and progression of neonatal vascular in synovium.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Type d'étude:
Étude pronostique
langue:
Chinois
Texte intégral:
Chinese Journal of Immunology
Année:
2010
Type:
Article
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