Effects of pyrroloquinoline quinone on proliferation and expression of NF-κB in cultured Schwann cells / 中国矫形外科杂志
Orthopedic Journal of China
; (24): 1647-1650, 2009.
Article
de Zh
| WPRIM
| ID: wpr-405423
Bibliothèque responsable:
WPRO
ABSTRACT
[Objective] To investigate the effects of pyrroloquinoline quinine (PQQ) on proliferation and expression of NF - kB of Schwann cells. [Methods] Schwann cells were cultured from sciatic nerves of SD rats in vitro. The Schwann cells were identified and purified by immunofluorescence of S-100 and Ara-C. Experimental group with was 100 nmol/L of PQQ and control group were set up. The expression of NF-kB in Schwann cells was determined by RT-PCR and Western blotting. [ Results] The expression of NF - kB were up - ragulated by PQQ in cultured Schwann cells (P<0.05).[Conclusion ] PQQ could promote the proliferation of Schwann cells and up-regulation of NF-rd3 play an important role in this process.
Texte intégral:
1
Indice:
WPRIM
langue:
Zh
Texte intégral:
Orthopedic Journal of China
Année:
2009
Type:
Article