Pathological changes of limiting membrane surrounding sterile artificial hip joint loosened prosthesis / 中国组织工程研究
Chinese Journal of Tissue Engineering Research
;
(53): 6985-6988, 2008.
Article
Dans Chinois
| WPRIM
| ID: wpr-407009
ABSTRACT
BACKGROUND:
Recent studies indicate that osteolysis surrounding prosthesis is the main reason causing artificial joint loosening.The reason and development process of osteolysis surrounding prosthesis are not fully understood.OBJECTIVE:
To observe the pathological changes of limiting membrane surrounding sterile loosened prosthesis of artificial hip ioint and compare that with cicatricial tissue surrounding internal fixation.DESIGN,TIME ANDSETTING:
Histological observation was done at The Second Hospital of Soochow University between September 2000 and December 2005.PARTICIPANTS:
Limiting membrane surrounding prosthesis of eight artificial hip joints overhauled for loosening were removed during operation for pathological examination.METHODS:
Specimens were fixed with 10%formaldehyde solution and embedded with paraffin,and were cut into sections,the sections were stained by hematoxylin-eosin(HE)staining and immunohistochemistry staining.The specimens were done bacterial culture.MAIN OUTCOMEMEASURES:
Histopathological changes.RESULTS:
Wear particles,cellular proliferation and osteolytic factors were found in the limiting membrane surrounding loosening prosthesis.The bacterial culture results of the specimens were negative.CONCLUSION:
Wear particles generated in the using process of prosthesis can activate osteolytic factors produced by inflammatory cells and is an important reason leading to sterile loosening of prosthesis.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Chinese Journal of Tissue Engineering Research
Année:
2008
Type:
Article
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