Functional polymorphism of CYP2E1 gene and alcohol use disorders in a Tibetan population / 中南大学学报(医学版)

ABSTRACT

Objective To investigate the relationship between the CYPphism and alcohol use disorders, and the potential influence of the CYP2E1 * c1/* c2 polymorphismon the severity and dimensions of alcohol use disorders in Tibetan. Methods Three hundred and forty Tibetans with Alcohol Use Disorders Identification Test (AUDIT) score I>10 and another 315 matched control subjects with AUDIT score ≤5 were enrolled. The CYP2E1 * c1/* c2 polymorphism was de-termined by the standard PCR-RFLP method. Results The frequency of the CYP2E1 * c2 allele in subjects with alcohol use disorders ( 16. 2 % ) was significantly higher than that of the controls(10.8%) , with a P value of 0. 005 and OR value of 1.60 (95% CI 1.15～2.21). There was also a significant difference in genotype frequencies between the 2 groups ( χ2= 8.75, P = 0.01).Subjects with alcohol use disorders had higher frequencies of genotypes with at least one copy of allele c2 (28.5% vs. 18.7%; χ2=8.65, P=0.003; 0R=1.73) than the control group. The associ-ation of CYP2E1 * c2 allele with alcohol use disorders was much stronger in males than in females,with a male OR value of 2.30. CYP2E1 * c2 allele was associated with increased alcohol consumption and alcohol use disorders in males. Conclusion There is the positive association among CYP2E1 * c2 allele, alcohol use disorders, and the amount of alcohol consumption in Tibetan population.